Personalizing chronotherapy of immune checkpoint blockade.

ABSTRACT: Emerging evidence highlights the critical role of time-of-day (ToD) in immunotherapy, with large-scale retrospective studies showing that administering immune checkpoint inhibitors (ICIs) earlier in the day is associated with significantly improved efficacy across all cancer types. This observation aligns with our growing understanding of the circadian system, our internal biological clock, which governs a range of physiological processes, including immune regulation, over a 24-hour scale. Each individual possesses a distinct pace in their circadian rhythm, known as their chronotype, which reflects their natural preference for morning or evening activity, performance and rest. Chronotype has already proven to be a valuable predictor of outcomes in other areas of healthcare, and its applica

SUBMITTER: Ismail-Sutton S 

PROVIDER: S-EPMC12581061 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature