Fixed airway obstruction and bronchodilator responsiveness phenotypes in severe asthma population from SANI registry.

ABSTRACT:

Background

Data on asthma with fixed airway obstruction (FAO) are heterogeneous due to different and misleading definitions. Describing the FAO phenotype has significant implications for severe asthma (SA) comprehension.

Objective

To characterise SA patients with FAO in the Severe Asthma Network in Italy (SANI) registry at baseline, and to compare with those with reversible airway obstruction (bronchodilator responsiveness, BDR). The potential for re-evaluating FAO or BDR in the follow-up was explored.

Methods

FAO was defined as a forced expiratory volume in the first second (FEV₁)/forced vital capacity ratio < Lower Limit of Normal (LNN) after a bronchodilator test with an increase in FEV₁ of <12% or 200 mL, compared with BDR and no airway obstr

SUBMITTER: Guida G 

PROVIDER: S-EPMC12581063 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature