Sublobar resection or lobectomy for stage Ia non-small cell lung cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

This systematic review and meta-analysis synthesises evidence from both randomised trials and observational studies to determine whether lobectomy or sublobar resection offers improved outcomes for patients with stage Ia non-small cell lung cancer (NSCLC).

Methods

Studies (up to June 2025) comparing lobectomy and sublobar resection (segmentectomy or wedge) for clinical stage Ia NSCLC (<2 cm) were included in the random-effects meta-analyses. Risk of bias was assessed using Risk of Bias 2 for randomised trials or Risk of Bias in Non-randomised Studies of Interventions-I for observational studies.

Results

19 studies, including four randomised trials, were included. Overall survival at 5 years was comparable between lobectomy and sublobar resection (HR=1.00; 9

SUBMITTER: Dixon LK 

PROVIDER: S-EPMC12581064 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature