Systemic immunosuppression from ultraviolet radiation exposure inhibits cancer immunotherapy.

ABSTRACT:

Background

Ultraviolet radiation (UVR) affects local cutaneous and systemic immunity acutely. The wavelength, pattern and intensity of UVR exposure, individual skin phototype and immune state of individuals modulate the impact of UVR systemically. Local cutaneous immunity after UVR leads to immunosuppression that impacts melanoma. However, the effects of systemic UVR-induced changes on solid cancer therapy are not known.

Methods

We investigated the impact of repeated UVR exposure on systemic immunity and immune checkpoint blockade (ICB) tumor responses in colorectal cancer and melanoma mouse models.

Results

Animals exposed to chronic UVR exhibit decreased ICB response, which is mediated by systemic factors. Repeated UVR exposure expanded systemic lymphocyte population

SUBMITTER: Durao P 

PROVIDER: S-EPMC12581074 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature