Impact of birth weight on cardiovascular disease and mediating role of metabolic traits: a Mendelian randomisation study.

ABSTRACT:

Background

Birth weight (BW) has been linked to cardiometabolic diseases, but causal associations with a comprehensive range of cardiovascular outcomes and underlying metabolic mechanisms remain unclear.

Methods

We applied a two-sample Mendelian randomisation (MR) approach to evaluate causal relationships between genetically predicted BW and 16 distinct cardiovascular diseases (CVD). We further conducted a two-step MR mediation analysis to quantify the mediating roles of 24 metabolic traits covering body composition, glucose metabolism, lipid metabolism, blood pressure, fatty acids and amino acids.

Results

Genetically lower BW was associated with higher risks of coronary heart disease (OR 0.72, 95% CI 0.65 to 0.81), myocardial infarction (OR 0.71, 95% CI 0.63 to 0.80)

SUBMITTER: Zhuang J 

PROVIDER: S-EPMC12581085 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature