Ligand-free reductive amination <i>via</i> Pd-coated mechanocatalysis.

ABSTRACT: Reductive amination under direct mechanocatalysis was enabled by a sequential two-frequency milling protocol, separating imine formation and hydrogenation. Strongly hydrophobic liquid additives accelerated the reaction by enhancing water exclusion. This approach allowed amine yields of up to 88% and was applicable to various aldehydes, ketones, and primary or secondary amines.

SUBMITTER: Wohlgemuth M 

PROVIDER: S-EPMC12581175 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature