Characterization of two novel Negevirus strains and analysis of global Negevirus distribution and host diversity.

ABSTRACT: Mosquitoes and mosquito-borne viruses pose a significant global public health concern. Furthermore, mosquitoes carry a wide range of insect-specific viruses (ISVs), and studying these ISVs is important due to their potential influence on mosquito behavior and the transmission of mosquito-borne viruses. In this study, we report the first isolation of two Negevirus strains from Aedes and Culex mosquitoes in Xinjiang, China: Dezidougou virus (DEZV, isolate XJ-ALT23-420-01) and Negev-like virus (NEGLV, isolate XJ-JH20-91-01). Phylogenetically, the nucleotide sequence of DEZV exhibits high similarity (98.96%) with the DEZV isolate 8345 from Germany but shows lower similarity (< 91.91%) with other DEZV strains. In contrast, the NEGLV isolate XJ-JH20-91-01 displays significant divergence from oth

SUBMITTER: Li Z 

PROVIDER: S-EPMC12581222 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature