Dietary amino acids and the odds of metabolic dysfunction-associated fatty liver disease (MAFLD) among overweight and obese children and adolescents: a principal component analysis approach.

ABSTRACT:

Background

Given the limited understanding of how dietary amino acid intake affects metabolic dysfunction-associated fatty liver disease (MAFLD), we examined the potential relationship between dietary amino acid patterns and the odds of MAFLD in children and adolescents with overweight and obesity.

Methods

This cross-sectional study was conducted on participants aged 6 to 18 years with a WHO body mass index (BMI)-for-age z-score ≥ 1. MAFLD diagnosis followed established consensus definitions. Principal component factor analyses were conducted based on eighteen amino acids. Logistic regression models, adjusted for potential confounders, were used to estimate the odds of MAFLD across amino acid profile score quartiles.

Results

A total of 505 (52.9% boys) with mean ± SD

SUBMITTER: Nikparast A 

PROVIDER: S-EPMC12581225 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature