Tissue inhibitor of metalloproteinase-2 predicts early allograft dysfunction after liver transplantation.

ABSTRACT:

Background

The lack of objective criteria to assess graft integrity represents a major impediment to the acceptance of livers of limited quality as a way to increase the donor pool in liver transplantation. Extracorporeal machine perfusion prior to transplantation may serve as a valuable platform to second to the surgeon's decision on acceptance or discard of the organ, but, to date, the availability of valuable perfusate biomarkers is rather poor. Tissue inhibitor of metalloproteinase-2 (TIMP2) is a protein actively secreted upon epithelial cell stress and involved in the suppression of endothelial cell proliferation.

Methods

A total of 20 livers grafts from extended criteria donors, which were shipped to the implantation clinic by conventional cold storage, were subjected

SUBMITTER: von Horn C 

PROVIDER: S-EPMC12581249 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature