Sulfur starvation induces an Fe-replete response and attenuates virulence pathways in Pseudomonas aeruginosa PAO1.

ABSTRACT:

Background

Understanding bacterial responses to nutrient limitation is critical for developing targeted antimicrobial strategies. Sulfur starvation uniquely induces not only genes responsible for sulfur scavenging but also prominent antioxidant defenses. However, the biological rationale behind the simultaneous induction of antioxidants during sulfur limitation remains largely unexplored. Our study addresses this gap by integrating transcriptomic, proteomic, and targeted metabolomic data from Pseudomonas aeruginosa PAO1 grown under sulfur-free conditions.

Results

As anticipated, transcripts and proteins involved in sulfur assimilation and metabolism-including members of the msu, ssu, and cys operons-were upregulated, along with key antioxidant enzymes such as Ohr, LsfA, and

SUBMITTER: Ugochukwu CG 

PROVIDER: S-EPMC12581299 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature