Downregulation of PDIA4 inhibits proliferation and migration in human oral squamous cell carcinoma.

ABSTRACT:

Background

Protein disulfide isomerase family A member 4 (PDIA4), a member of the protein disulfide isomerase family, has been associated with the progression of cancer. Nevertheless, its specific function in oral squamous cell carcinoma (OSCC) is not yet well understood.

Methods

To assess the prognostic significance and functional profile of the PDIA4, survival analysis and GSEA were conducted. Additionally, we examined the differences in immune infiltration and immunotherapy response between groups with low and high expression levels of PDIA4. Subsequently, RT-qPCR and western blot assays were employed to verify PDIA4 expression in OSCC tissues. The functional implications of PDIA4 in OSCC cells were also investigated.

Results

Analysis of the TCGA-OSCC dataset revea

SUBMITTER: Hu Y 

PROVIDER: S-EPMC12581318 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature