Remote ischemic postconditioning improves cognitive dysfunction after subarachnoid hemorrhage by driving metabolic reprogramming of border-associated macrophages through the IL-33/ST2 axis.

ABSTRACT:

Background

Subarachnoid hemorrhage (SAH) is a critical cerebrovascular disease with high mortality and morbidity. Despite advances in treatments that have reduced mortality, survivors frequently suffer from persistent cognitive dysfunction. Border-associated macrophages (BAMs) play essential nutritional and immunoregulatory roles in neurological diseases; however, their dynamic alterations following SAH and their effects on cognitive outcomes remain unclear. Remote ischemic postconditioning (RIPostC) is an emerging neuroprotective approach, but its mechanisms in the context of SAH have not been fully elucidated. This study aimed to investigate the role of BAMs in cognitive dysfunction after SAH and to explore the effects and underlying mechanisms of RIPostC intervention.

Methods

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12581351 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature