Blocking CCR1⁺ macrophages overcomes resistance to immune checkpoint inhibitors in melanoma.

ABSTRACT: Chemokines and their receptors play a pivotal role in shaping the tumor microenvironment (TME) and modulating immune responses by orchestrating immune cell recruitment, spatial positioning, and facilitating cell-cell interactions. However, the exact mechanisms underlying chemokine signaling across different cell populations within the TME remain poorly understood. In this study, we utilized multiple-omics approaches to explore the relationship between CCR1⁺ macrophages, CD8⁺ exhausted T (Tex) cells, and immune checkpoint blockade (ICB) therapy response, as well as the role of chemokine signaling in the formation of CCR1⁺ macrophage and CD8⁺ Tex cell niches. We found that CCR1⁺ macrophages were closely associated with ICB outcomes in me

SUBMITTER: Su X 

PROVIDER: S-EPMC12581358 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature