Age-related regional homogeneity changes in first-episode major depressive disorder: a REST-meta-MDD project study.

ABSTRACT: Major depressive disorder (MDD) is associated with altered spontaneous brain activity, commonly assessed by regional homogeneity (ReHo), a measure of local synchronization of neuronal synchronization. While previous research has highlighted ReHo changes in MDD, their age-related variations remain underexplored. To address this, this study investigated first-episode MDD patients from the REST-meta-MDD project, dividing them into three age subgroups: young (16-24 years), adults (25-39 years), and middle-aged participants (40-54 years), and examined the age-related ReHo changes and interactions with disease. The results revealed distinctive age-specific patterns of ReHo alternations. Specifically, young patients showed decreased ReHo in the right middle frontal gyrus, right superior parietal

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12581383 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature