Microbial biomarkers and sex-associated gut microbiota characteristics of thyroid cancer.

ABSTRACT: Microbial biomarkers have emerged as promising tools for early cancer detection and disease monitoring. This study aimed to investigate microbial biomarkers and sex-associated differences in gut microbiota associated with thyroid cancer (TC). A total of 268 participants were recruited: 60 females with TC, 26 males with TC, and 182 healthy controls. The patient and healthy groups were comparable in terms of age and sex ratio. We first compared the gut microbiota between the patients and healthy participants, followed by sex-specific analyses: female patients vs. female controls, and male patients vs. male controls. Predictive models were used to explore the role of gut microbiota in predicting TC. Correlations between gut microbiota and T stage (i.e., T1 to Tx) were also investigated. The a

SUBMITTER: Gou J 

PROVIDER: S-EPMC12581412 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature