Thrombotic microangiopathy associated with mantle cell lymphoma: a case report.

ABSTRACT:

Background

Thrombotic microangiopathy (TMA) is a syndrome characterized by vascular endothelial cell damage, with anemia, thrombocytopenia, and thrombus-related organ damage. Secondary TMA is caused by various factors, including hematological malignancy. Case reports on TMA with mantle cell lymphoma (MCL) are extremely rare. Herein, we report a case of secondary TMA wherein MCL was diagnosed based on the same kidney biopsy specimen and treated with chemotherapy, resulting in improvement in TMA.

Case presentation

A 60-year-old man was admitted to our hospital for acute kidney injury with TMA and focal interstitial lymphocytic infiltration, which was detected by kidney biopsy performed at a previous hospital. Plasma exchange, hemodialysis, and steroid therapy were initiated; h

SUBMITTER: Tonouchi Y 

PROVIDER: S-EPMC12581422 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature