Small intestinal bacterial overgrowth and dysbiosis in children with intestinal failure: A descriptive cohort study.

ABSTRACT:

Background

Small intestinal bacterial overgrowth (SIBO) is a clinical and diagnostic challenge in pediatric intestinal failure. This study aimed to assess SIBO and dysbiosis in children with intestinal failure and to analyze clinical characteristics as well as cultural and metagenomic sequencing results from different sampling methods.

Methods

Descriptive, single-center cohort study in intestinal failure patients with prospective collection of intraluminal aspirate, epithelial brush swab, mucosal biopsy, and small bowel stoma stool for SIBO diagnosis, defined as ≥10³ CFU/ml of enteric, colonic-type bacteria, and microbiome analysis via whole-genome sequencing. Statistical testing included receiver operating characteristic analysis, chi-square test, and independent

SUBMITTER: Hilberath J 

PROVIDER: S-EPMC12581465 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature