Fatty acid profiles in blood and tissues of parenteral nutrition-fed neonatal piglets using a novel lipid emulsion containing choline.

ABSTRACT:

Background

For parenteral nutrition (PN)-dependent neonates, soybean oil intravenous lipid emulsions (SO-ILEs) and mixed emulsions (SO, medium-chain triglyceride [MCT], olive oil [OO], and fish oil [FO] ILEs) are likely not providing adequate amounts of key fatty acids (FAs) arachidonic acid (AA) and docosahexaenoic acid (DHA) and are devoid of choline. Current FO-containing ILEs provide excessive amounts of eicosapentaenoic acid (EPA). In neonatal piglets, we compared a novel lipid (NOV-C) with the addition of AA, DHA, and choline while sparing EPA with SO-ILE and SO,MCT,OO,FO-ILE.

Methods

We compared FA deposition in serum and tissues among groups of neonatal piglets fed exclusive PN based on SO-ILE (n = 7), SO,MCT,OO,FO-ILE (n = 7), or NOV-C (n = 8). On day 14, serum, liv

SUBMITTER: Pauline ML 

PROVIDER: S-EPMC12581466 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature