Association between mixed fatty acid emulsion and parenteral nutrition-associated cholestasis in extremely low-birth-weight infants: A retrospective cohort study.

ABSTRACT:

Background

Soybean oil lipid emulsions have been implicated in the development of parenteral nutrition-associated cholestasis (PNAC) in premature infants. A recent mixed fatty acid emulsion containing soybean oil, medium-chain triglycerides (MCTs), olive oil, and fish oil may reduce the incidence of PNAC, but evidence remains conflicting. The aim of this study was to evaluate the effect of mixed fatty acid emulsion on PNAC in extremely low-birth-weight (ELBW) infants.

Methods

We performed a retrospective cohort study on ELBW infants from 2016 to 2022. ELBW infants who received MCT/long-chain triglyceride (LCT) lipid emulsion or mixed fatty acid emulsion were compared. The primary outcome was the incidence of PNAC. Secondary outcomes included peak levels of direct bilirubin a

SUBMITTER: Xie T 

PROVIDER: S-EPMC12581467 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature