Association between respiratory-related cortical activation and weaning from mechanical ventilation: a physiological study.

ABSTRACT:

Background

In mechanically ventilated patients, extubation is decided after passing a spontaneous breathing trial (SBT). Supplementary motor area, which can be non-invasively assessed by measuring amplitude of pre-inspiratory potentials (PIPs), is recruited in case of increased respiratory effort. Weaning failure may be accompanied by increased respiratory effort. We hypothesized that early increased PIP amplitude from the start of SBT may be associated with SBT failure.

Patients and methods

We performed a single-center physiological prospective study in mechanically ventilated patients meeting weaning criteria. PIP amplitude was measured using electroencephalography under mechanical ventilation and then during the first 15-min of the SBT performed using a T-piece. We compar

SUBMITTER: Rault CCS 

PROVIDER: S-EPMC12581473 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature