Tumor budding predicts lymph node metastasis in squamous cell carcinoma of the lip.

ABSTRACT:

Background

Squamous cell carcinoma of the lip (LSCC) is a relatively rare malignancy. The criteria for performing a neck dissection remain unclear, as reliable predictors for lymph node metastasis (LNM) have not been fully established. This study aimed to identify risk factors for LNM to guide the indication for elective neck dissection.

Methods

A total of 57 patients with LSCC were evaluated based on 81 clinical and pathological parameters, including three previously published pathological grading systems. Statistical analyses focused on identifying the most relevant and independent predictors of LNM using univariate and multivariate logistic regression, supplemented by the LASSO algorithm for feature selection.

Results

Tumor size (OR 1.008, p = 0.85) and peritumoral

SUBMITTER: Leypold S 

PROVIDER: S-EPMC12581523 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature