IGF1-mediated mesenchymal-endothelial transition as a potential regulatory target in calcific aortic valve disease.

ABSTRACT:

Background

Aortic valve interstitial cells (VICs) are considered a highly plastic heterogeneous mesenchymal cell population. Although previous studies have demonstrated their potential to differentiate into myofibroblasts, osteoblasts, chondrocytes, and adipocytes, their ability to differentiate into endothelial cells has not been confirmed. Notably, normal aortic valve tissue is avascular, but in the diseased valves of patients with calcific aortic valve disease (CAVD), we often find cells with an endothelial phenotype, but the origin of these cells is unclear.

Methods

We performed paraffin section immunofluorescence analysis on calcified aortic valves from 16 patients with CAVD. Primary VICs and valve endothelial cells (VECs) were isolated from normal porcine aortic valves

SUBMITTER: Li B 

PROVIDER: S-EPMC12581533 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature