Dimethyl fumarate alleviates inflammation during high altitude hypoxia induced acute lung injury by upregulating Nrf2/SLC7A11 pathway in ferroptosis.

ABSTRACT:

Background

This study aims to investigate the impact of high altitude (HA) hypoxia on ferroptosis in lung tissue and the evaluate the preventative effect of Dimethyl fumarate (DMF) on lung inflammation.

Methods

Proteomic analysis was performed in plasma of volunteers ascending to high altitude, lung tissue of ALI rats, co-cultured lung epithelial (BEAS-2B cells) and macrophages (THP-1 cells) under hypoxia, either individually or in co-culture setting. DMF was pre-treated with rats or BEAS-2B cells before ferroptosis indexes and inflammatory cytokines were determined. Knock-down or overexpression of SLC7A11 in BEAS-2B cell was performed to further verify the role of DMF in alleviating ferroptosis and inflammation in ALI.

Results

Proteomic analysis of human plasma, rat

SUBMITTER: Wang C 

PROVIDER: S-EPMC12581550 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature