Therapeutic efficacy of multiple neoadjuvant regimens involving targeted therapy, immunotherapy and chemotherapy in gastric cancer: a systematic review and meta-analysis.

ABSTRACT:

Backgroud

The utilization of neoadjuvant therapy, encompassing chemotherapy, molecular targeted therapy, and immunotherapy, has demonstrated a significant enhancement in the radical resection rate and an improved prognosis for patients with locally advanced gastric cancer (LAGC). The purpose of this meta-analysis was to evaluate the efficacy and safety of neoadjuvant chemotherapy (NCT) in combination with targeted therapy or (and) immunotherapy for LAGC patients.

Methods

The PubMed, EmBase, and Cochrane Library databases were systematically searched to identify clinical studies comparing the efficacy of different neoadjuvant regimens in LAGC patients. Subsequently, paired and network meta-analyses were conducted using Stata software to evaluate the pooled results of differen

SUBMITTER: Liang C 

PROVIDER: S-EPMC12581565 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature