Thiamine use and short-term prognosis in critical cerebrovascular disease: a propensity score matched retrospective analysis from the MIMIC-IV database.

ABSTRACT:

Background

In the realm of critical care, cerebrovascular disease remains a major factor in patient morbidity and mortality, with limited treatment options outside of acute interventions. The importance of thiamine (vitamin B1) in energy metabolism is well-known, and it may provide neuroprotective benefits, though its role in serious cerebrovascular diseases is still uncertain.

Methods

Using data from the MIMIC-IV database, this retrospective cohort study explored the relationship between thiamine and short-term outcomes in patients with critical cerebrovascular conditions. The application of propensity score matching (PSM) helped to balance covariates between users and non-users of thiamine. The study's primary and secondary endpoints were the all-cause mortality at 7, 14,

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12581575 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature