Longitudinal change of idiopathic inflammatory myopathy-associated interstitial lung disease on high-resolution computed tomography, a prospective cohort study.

ABSTRACT:

Background

This study aimed to investigate longitudinal change of idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) on high-resolution computed tomography (HRCT).

Methods

This prospective cohort study was undertaken involving 514 IIM-ILD patients (367 females; median age 54 years) from 2016 to 2022. Deep learning algorithms were employed to quantify interstitial lesions on HRCT, while clinical parameters including pulmonary function tests, serum biomarkers, and arterial blood gas analysis were also considered.

Results

The study identified anti-MDA5 antibody positivity (OR: 10.46, 95% CI: 3.40-32.22), reduced FVC (OR: 0.91, 95% CI: 0.84-0.98), and extensive ground-glass opacity (GGO) (OR: 1.07, 95% CI: 1.01-1.13)/ reticulation (OR: 1.23, 9

SUBMITTER: Qiang Y 

PROVIDER: S-EPMC12581610 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature