Anti-inflammatory effect of lamivudine on ulcerative colitis.

ABSTRACT: Ulcerative colitis (UC) is a non-specific inflammatory bowel disease characterized by ulcers and erosions in the colonic mucosa, leading to a chronic cycle with alternating periods of remission and exacerbation. Ascribed to its elusive etiology, primary therapy is limited to symptomatic treatment. Consequently, there is a pressing need to identify novel therapeutic agents for UC. Lamivudine, a nucleoside analog known for its antiviral properties and Long Interspersed Nuclear Element 1 (LINE-1) inhibitory effects, was investigated for its potential anti-inflammatory role in UC. Thus, this study aimed to investigate the anti-inflammatory effect of lamivudine on DSS (Dextran Sulphate Sodium)-induced ulcerative colitis (UC) in mice. Briefly, the mice were randomly assigned to the control group

SUBMITTER: Chen X 

PROVIDER: S-EPMC12581620 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature