Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions.

ABSTRACT: The phosphorylation of the ribosomal protein S6 (RPS6) was reported to be increased in myeloid cell subsets after stimulation with peanut extract in peanut-allergic individuals or with anti-IgE antibodies in both allergic and nonallergic donors. The mechanisms driving this increase of RPS6 phosphorylation (pS6) and its clinical impacts remain to be elucidated. Therefore, we investigated the mechanism of pS6 induction in plasmacytoid DCs (pDCs) and conventional DCs (cDCs) using whole blood stimulated with peanut extract or anti-IgE antibodies. This approach included in vitro basophil depletion and the application of receptor antagonists. Clinical associations with differential pS6 were performed with data from a well-defined cohort of peanut-allergic individuals participating in the food in

SUBMITTER: Fauchere F 

PROVIDER: S-EPMC12581671 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature