Lower, more frequent cisplatin dosing minimizes hearing loss in head and neck cancer.

ABSTRACT: BACKGROUNDCisplatin is often the cytotoxic drug of choice for chemoradiation therapy (CRT) for head and neck squamous cell carcinoma (HNSCC), but it can lead to irreversible hearing loss. There may be similar oncologic outcomes but different toxicity profiles depending on whether cisplatin is given at 75-100 mg/m2 every 3 weeks or 30-40 mg/mg2 weekly. This study compares cisplatin-induced hearing loss in patients with HNSCC receiving similar cumulative doses of cisplatin administered either on higher-dose or lower-dose treatment schedules.METHODSUsing the Enhancing Cancer Hearing Outcomes (ECHO) dataset from 5 academic centers, we conducted a multicenter retrospective cohort study of adults (≥18 years) with HNSCC receiving cisplatin-based CRT. Participants were grouped by cisplatin dose sc

SUBMITTER: Fernandez KA 

PROVIDER: S-EPMC12581672 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature