Baseline and long-term frailty transitions and rapid estimated glomerular filtration rate decline: evidence from two large population-based studies.

ABSTRACT: Frailty is widely recognized to be associated with kidney function decline, but its longitudinal relationship with rapid estimated glomerular filtration rate (eGFR) decline remains unclear. This study examined associations between frailty measures and rapid eGFR decline using both frailty phenotype (FP) and frailty index (FI) in two large cohorts. We analyzed baseline frailty data from the China Health and Retirement Longitudinal Study (CHARLS) and Health and Retirement Study (HRS), with longitudinal trajectory analysis in HRS participants. Rapid eGFR decline was defined as annual decrease ≥4 mL/min/1.73 m²/year. Multiple imputation with inverse probability weighting addressed missing data and selection bias. Using FP criteria, frailty was significantly associated with higher od

SUBMITTER: Deng Y 

PROVIDER: S-EPMC12581771 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature