Multifunctional Nanovaccine Sensitizes Breast Cancer to Immune Checkpoint Therapy.

ABSTRACT: Breast cancer is the primary cause of cancer-related death in women worldwide. Breast cancer subtypes are characterized by different gene expression patterns, which drive their prognostic factors and therapeutic options. Among them, triple-negative breast cancer (TNBC) is one of the deadliest due to its aggressiveness, high rate of early recurrence and distant metastases, and limited therapeutic options. Despite the recent approval of monoclonal antibodies targeting programmed cell death protein 1 (PD-1) or its ligand (PD-L1) for the treatment of TNBC patients with a locally recurrent unresectable or metastatic tumor expressing PD-L1, their response rate is very modest. It is reported that polymeric nanoparticle (NP)-based cancer vaccines, co-entrapping tumor-associated antigens, Toll-like

SUBMITTER: Peres C 

PROVIDER: S-EPMC12581784 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature