TaxaGO: a novel, phylogenetically informed gene ontology enrichment analysis tool.

ABSTRACT: The functional interpretation of genes and their protein products across diverse species remains a central challenge in genomics, particularly as datasets grow in scale and complexity. The Gene Ontology (GO) knowledgebase offers a detailed resource of accessing a gene's function. While GO enrichment analysis tools are widely used to uncover biological insights, they are designed for single-species analyses and are not able to integrate phylogenetic relationships into the enrichment analyses. To address this, we created TaxaGO, a high-performance, multi-taxonomic GO enrichment analysis tool that incorporates evolutionary distances with species-level enrichment results to unravel GO enrichment profiles at a taxonomic level. Implemented in Rust for speed and scalability, TaxaGO enables robust

SUBMITTER: Bochalis E 

PROVIDER: S-EPMC12581831 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature