Elevated SLC1A5 links to inflamed endothelial cells and proteinuria in membranous nephropathy patients.

ABSTRACT:

Background

Membranous nephropathy (MN) is an autoimmune glomerular disorder characterized by persistent proteinuria. Elucidating its pathophysiological mechanisms and signaling pathways is crucial for improving diagnostic and therapeutic strategies.

Methods

We performed differential analysis on the MN glomerular transcriptome and assessed immune infiltration. Single-cell analysis identified key genes' subcellular localization, while pseudotime and cell communication analyses determined subpopulations linked to MN progression. Genes causally related to MN onset were screened using Mendelian randomization, and serum core genes were correlated with proteinuria via ELISA.

Results

Transcriptome analysis revealed 95 differentially expressed genes, predominantly enric

SUBMITTER: Tang Q 

PROVIDER: S-EPMC12581921 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature