NIR-Activatable, Sequence-Specific Metal-Nucleic Acid Scaffolds for Responsive Uncaging.

ABSTRACT: Precise molecular activation with both analyte specificity and spatiotemporal control remains a major challenge in responsive diagnostics, targeted therapies, and the study of complex biological systems. Traditional photo-uncaging strategies offer excellent temporal resolution but suffer from limited tissue penetration and poor biological specificity, while analyte-responsive platforms provide molecular selectivity without external control. Here, we introduce sequence-responsive diagnostic uncaging-a unique approach that integrates nucleic acid recognition with near-infrared (NIR)-triggered molecular activation within a metal-nucleic acid scaffold. This platform is built upon a first-of-its-kind Pt(IV)-DNA molecular scaffold, modularly assembled via click chemistry, and integrates a Pt(IV)

SUBMITTER: Sharma A 

PROVIDER: S-EPMC12582009 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature