<i>Leishmania amazonensis</i> infection induces IL1β-dependent hyperalgesia, while dampening mechanical allodynia in C57BL/6 mice.

ABSTRACT: Leishmaniasis is a group of neglected diseases that cause significant mortality and disability. In Brazil, the most prevalent form is cutaneous leishmaniasis, which is characterized by painless lesions despite intense inflammation and ulceration. While BALB/c mouse models exhibit hypersensitivity to inflammatory stimuli, C57BL/6 mice better mimic human-like lesion progression and nociception. This study aimed to investigate the mechanisms underlying nociception in cutaneous leishmaniasis using the C57BL/6 model. Following infection with L. amazonensis, behavioral and nociceptive tests revealed unaltered mechanical nociception and motor capacity, although thermal hyperalgesia was observed during the chronic phase. Elevated IL-1β production in lesions and upregulation of TRPV1 in dors

SUBMITTER: Perez GG 

PROVIDER: S-EPMC12582110 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature