Master transcriptional regulator SaeS in <i>Staphylococcus aureus</i> contributes to staphyloxanthin biosynthesis to promote survival during invasive infection.

ABSTRACT: Staphylococcus aureus is a major human opportunistic pathogen that causes significant morbidity and mortality, particularly in immunocompromised individuals. SaeRS is a two-component system in S. aureus that regulates signal transduction related to virulence, including hemolysis and coagulation. Metal ions are essential nutrients that support bacterial virulence and survival against host immune cells and are intricately interconnected with regulatory systems. The SaeRS system has long been studied for its function in bacterial virulence and invasive infections. However, its interactions with other regulators and metal ions remain unelucidated. Thus, this study evaluated the effects of the S. aureus SaeRS system on virulence, specifically its association with oxidative

SUBMITTER: Bae E 

PROVIDER: S-EPMC12582123 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature