Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency.

ABSTRACT: Intercellular mitochondrial transfer, the spontaneous exchange of mitochondria between cells, is a recently described phenomenon crucial for cellular repair, regeneration, and disease management. Enhancing this natural process holds promise for developing novel therapies targeting diseases associated with mitochondrial dysfunction. Here, we introduce a nanomaterial-based approach employing molybdenum disulfide (MoS₂) nanoflowers with atomic-scale vacancies to stimulate mitochondrial biogenesis in cells to make them mitochondrial biofactories. Upon cellular uptake, these nanoflowers result in a two-fold increase in mitochondrial mass and enhancing mitochondrial transfer to recipient cells by several-fold. This enhanced efficiency of transfer significantly improves mitochondrial r

SUBMITTER: Soukar J 

PROVIDER: S-EPMC12582283 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature