Deficits in sustained attention in adolescents with bipolar disorder during their first manic episode.

ABSTRACT:

Objectives

Evaluate differences in sustained attention (SAT) and associated neurofunctional profiles between bipolar disorder type I (BD), attention-deficit/hyperactivity disorder (ADHD), and healthy comparison (HC) youth.

Methods

Adolescent participants, aged 12-17 years, with BD (n = 30) and ADHD (n = 28) and HC adolescents (n = 26) underwent structural and functional magnetic resonance imaging (fMRI) while completing a modified Continuous Performance Task-Identical Pairs task. Attentional load was modifying in this task using three levels of image distortion (0 %, 25 % and 50 % image distortion). Task related fMRI activation and performance measures: perceptual sensitivity index (PSI); response bias (RB) and response time (RT); were calculated and compared between groups.

SUBMITTER: Patino LR 

PROVIDER: S-EPMC12582379 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature