Prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.

ABSTRACT: Functional adipose tissue is essential for maintaining systemic metabolic homeostasis. Dysfunctional adipose tissue, characterized by increased fibrosis, hypoxia and chronic inflammation, is often associated with obesity and promotes the onset of metabolic disease, such as type 2 diabetes. During nutrient excess, adipose tissue function can be preserved by the generation of new adipocytes from adipocyte stem cells, illustrating the importance of identifying the physiological regulators of adipogenesis. Here, we discover a cilia-localized signaling pathway through which the pro-inflammatory lipid metabolite prostaglandin E2 (PGE2) suppresses adipogenesis. We demonstrate that PGE2 specifically signals through the E-type prostaglandin receptor 4 (EP4) localized to the primary cilium of adipoc

SUBMITTER: Lee MD 

PROVIDER: S-EPMC12582440 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature