Cytoarchitectural modifications and antiinflammatory strategies in tendinopathy recovery.

ABSTRACT: Tendinopathies (TPs) are complex conditions marked by inflammation, pain, and impaired function, often due to tendon overuse. Achilles tendinitis, a prevalent TP, affects both athletes and the general population. Despite available treatments, effective tissue regeneration remains elusive. This study investigates the molecular cytoarchitecture and protein expression in TP-related inflammation and evaluates the therapeutic potential of hydroxytyrosol (HT), maslinic acid (MA), glycine/aspartic acid (AA), and their combination with percutaneous intratissue electrolysis (EPI) in a Wistar rat model of induced TP. Animals received a diet supplemented by incorporating the compounds directly into the chow with MA (0.65 g/kg of diet), HT (3 g/kg of diet), and Gly/Asp (Gly: 28.125 g/kg of diet; Asp:

SUBMITTER: Ramos-Barbero M 

PROVIDER: S-EPMC12582488 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature