Identification of Seven in absentia homolog 2 as a potential efferocytosis-related biomarker in diabetic foot ulcers.

ABSTRACT:

Introduction

Wound of diabetic foot ulcers (DFU) is chronic and hard to heal, characterized by impaired inflammatory response, dysfunction of keratinocyte and endothelial cells and improper removal of dying cells. Efferocytosis, as a trigger for phenotype switch of macrophages, plays a critical role in diabetic foot wound healing. Here, we showed the effect of efferocytosis in wound healing of diabetics and identified seven in absentia homolog 2 (SIAH2) as a potential efferocytosis-related biomarker.

Methods

Blood and skin samples were collected from 20 patients diagnosed type II diabetes at Qilu Hospital of Shandong University. Efferocytosis related genes in DFU were identified based on GSE147890, GSE80178 datasets as well as RNA-seq data of blood samples. Enrichment analys

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12582498 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature