Rhesus macaques model human Mayaro virus disease and transmit to Aedes aegypti mosquitoes.

ABSTRACT:

Background

Mayaro virus (MAYV) is a mosquito-borne alphavirus endemic to Latin America that causes fever and arthritis. Unlike the related chikungunya virus, MAYV has not caused widespread, human-amplified epidemics. One possible explanation is that human viremia levels are too low to support transmission to urban Aedes (Stegomyia) aegypti mosquitoes. We used rhesus macaques (RM) to model human-to-Ae. aegypti transmission and to further expand understanding of their relevance to human MAYV disease.

Methodology/principal findings

Twelve RM were inoculated with a genotype D lineage MAYV from an infectious clone using one of 3 dose and route combinations: 7 log10 plaque forming units (PFU) intravenously (IV), 7 log10 PFU subcutaneously (SC), or 3 log10 PFU SC. Viremia was measu

SUBMITTER: Moore AJ 

PROVIDER: S-EPMC12582505 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature