A new Caenorhabditis elegans apurinic/apyrimidinic (AP) endonuclease engaged in rescue from replication stress-induced arrest.

ABSTRACT: Apurinic/apyrimidinic sites are one of the most frequent spontaneous lesions in DNA. Evolutionarily conserved AP endonucleases (ExoIII and EndoIV families) incise the DNA backbone 5' to the AP site and the cleaved AP sites are subsequently repaired by the base excision repair machinery. AP endonucleases additionally exhibit 3'-5' exonuclease activity. Novel AP endonucleases that are not member of AP endonuclease families keep being reported and exhibit 3'-5' exonuclease activity and other important DNA processing. Interestingly, human and mouse WRN helicases contain a 3'-5' exonuclease domain, but the precise functional roles of the exonuclease activity in vivo remain unclear. We searched for WRN-like exonuclease proteins in the Caenorhabditis elegans database and found a new gene, zk1098.

SUBMITTER: Choi S 

PROVIDER: S-EPMC12582537 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature