Association of Modifiable Lifestyle and Metabolic Factors With the Risk of Developing Sepsis: 2-Sample Mendelian Randomized Study.

ABSTRACT:

Background

Sepsis is a life-threatening condition characterized by organ dysfunction resulting from dysregulated host response to infections. Approximately 48.9 million people worldwide are diagnosed with sepsis annually, leading to 11 million deaths and representing 19.7% of all global deaths. No specific, effective treatments for sepsis, which has a poor prognosis, are available.

Objective

The study aimed to systematically explore the association between genetically predicted modifiable risk factors and sepsis.

Methods

Univariable 2-sample Mendelian randomization (MR) analysis was performed to explore the association between 30 modifiable risk factors (12 lifestyle, 3 educational and psychological, and 15 metabolic factors) and sepsis. Heterogeneity was evaluated us

SUBMITTER: Lv H 

PROVIDER: S-EPMC12582546 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature