Recognition of HSPB8 as a potential therapeutic target for prostate cancer.

ABSTRACT: Prostate cancer poses a serious burden on men's quality of life. Identifying novel biomarkers for therapeutic development and prognostic prediction has long been a focal point in prostate cancer research. HSP family is a group of molecular chaperones that exhibit close relationship with many cancer types. In this study we screened out HSPB8 as a potential biomarker using WGCNA. Then we analyzed its expression patterns, investigated its biological functions, and assessed its prognostic values with a combination of bioinformatic analyses and experimental validation. Our data demonstrated that HSPB8 exhibited lower expression levels in prostate cancer tissues than in normal prostatic tissues. As a tumor suppressor gene, lack of HSPB8 was associated with unfavorable survival outcomes among pat

SUBMITTER: Fu X 

PROVIDER: S-EPMC12582549 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature