Utility of metastasis-directed radiotherapy with and without hormonal therapy in management of oligometastatic prostate cancer.

ABSTRACT:

Background

Metastasis-directed radiotherapy (MDT) is the mainstay in management of oligometastatic prostate cancer (PCa), and PSMA-PET is currently the most sensitive imaging modality for localizing PCa metastases. The efficacy of MDT guided by PSMA-PET imaging with and without androgen deprivation therapy (ADT) ± androgen-receptor pathway inhibitor (ARPI) has not yet been well characterized. We sought to evaluate the efficacy of PSMA PET-guided MDT.

Methods

This is a single-institutional retrospective study of patients diagnosed with metastatic PCa by PSMA-PET imaging who were treated with MDT. Survival analyses were performed using the Kaplan-Meier method with Cox proportional hazards testing for significance. Cumulative incidence analyses were performed with Gray's testin

SUBMITTER: Chen WS 

PROVIDER: S-EPMC12582589 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature