Construction and Validation of a Risk Assessment Model for Sepsis-Associated Acute Lung Injury in Patients With Sepsis in the Intensive Care Unit.

ABSTRACT:

Purpose

Sepsis-associated acute lung injury (SALI) represents a severe complication in sepsis patients, leading to poor clinical outcomes and increased mortality. This study aimed to develop and validate a reliable nomogram for early prediction of SALI in adult critically ill patients, addressing the critical need for timely risk stratification and intervention.

Methods

A retrospective cohort study was conducted involving 345 intensive care unit sepsis patients from the First People's Hospital of Huzhou. Patients were randomly divided into training (n = 241) and validation (n = 104) cohorts. Multivariate logistic regression and LASSO regression were employed to identify independent risk factors and construct a predictive nomogram.

Results

Four independent risk factors

SUBMITTER: Weng L 

PROVIDER: S-EPMC12582624 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature