Causal effect between systemic inflammatory cytokines and osteoporotic pathological fractures: A bidirectional Mendelian randomization study.

ABSTRACT: Osteoporosis is a prevalent metabolic bone disorder that significantly impairs patients' quality of life. Mounting evidence suggests a close relationship between systemic inflammation and bone metabolism, yet the causal nature of this association remains unclear. This study aims to elucidate potential causal links between circulating inflammatory factors and osteoporotic pathological fractures. We employed a bidirectional 2-sample Mendelian randomization (MR) approach, utilizing large-scale genetic data from the FinnGen biobank (1822 osteoporosis cases and 3,11,210 controls) and the genome-wide association study catalog to analyze 91 circulating inflammatory factors. Instrumental variables were selected using a threshold of P < 1 × 10-5, followed by stringent linkage disequilibrium pruning

SUBMITTER: Wang H 

PROVIDER: S-EPMC12582674 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature