Association between the metabolic score for insulin resistance and osteoarthritis prevalence: A cross-sectional population-based study.

ABSTRACT: Insulin resistance (IR) is associated with osteoarthritis (OA). The metabolic score for insulin resistance (METS-IR) is a tool for evaluating IR without direct insulin measurement, demonstrating potential across many metabolic disorders. Nonetheless, its association with OA remains ambiguous. The National Health and Nutrition Examination Survey 2011-2018 data set was examined in this cross-sectional analysis. METS-IR was computed using widespread metabolic markers, and OA was determined by self-reported physician diagnosis. The association between METS-IR and OA was assessed using logistic regression models that controlled for comorbidities, lifestyle, and demographics. METS-IR was assessed both continuously and by quartiles. Restricted cubic splines were used to examine dose-response rela

SUBMITTER: Weng Y 

PROVIDER: S-EPMC12582681 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature