Employing plasma proteins in proteomic Mendelian randomization analysis to identify therapeutic targets for duodenal ulcer.

ABSTRACT: Proteomics serves as a primary source of therapeutic targets. In this study, we performed a Mendelian randomization (MR) analysis within the proteomic scope to identify candidate protein markers and potential therapeutic targets for duodenal ulcer (DU). This study utilized MR and co-localization analysis within the proteomic framework. Data on 2088 plasma proteins were carefully collected from a study that detected 4907 protein quantitative trait loci. The genetic association data for DU were sourced from the UK Biobank, which encompassed 1908 cases and 461,025 controls. MR used single nucleotide polymorphisms as a genetic tool to estimate the causal effects of exposure on outcomes, in order to screen candidate proteins associated with DU. Meanwhile, Bayesian co-localization analysis is us

SUBMITTER: Luo X 

PROVIDER: S-EPMC12582692 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature